clinical medicine research

Clinical Medicine Research

  • © 2018
  • Mieczyslaw Pokorski 0

Opole Medical School, Opole, Poland

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  • Advancing new ideas and knowledge
  • Innovative and insightful clinical research
  • Dissemination of best clinical practice

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1116)

Part of the book sub series: Clinical and Experimental Biomedicine (CLEXBI)

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About this book

This book presents an update on new trends and developments in broadly defined medical disciplines. The whole range of multidisciplinary topics are tackled, regarded as being important for advancing the understanding of disease pathogenicity, diagnostic methods, and patient management. The topics include a holistic approach to physiotherapy, with proprioceptive neuromuscular facilitation at the core of it, potential ways to protect kidneys during ischemic coronary interventions, and psychosocial aspects in cancer survivors. Other topics deal with growth hormone deficiency in short children and responses of molecular markers of bone metabolism to growth hormone replacement therapy and with the modern use of transcranial laser-induced photobiomodulation showing surprising benefits in autism disorder. The expert contributions take on the challenges presented to medical professionals by ever growing medical knowledge and various individual and contextual issues that require a multidisciplinary approach in patient management. The authors present a bench-to-bed clinical research to make useful additions to the knowledge on contemporary diagnostic procedures, therapy, and quality of life of patients. The book aims to provide stimulus for new research ideas and to give new perspectives on practical clinical issues. The book is intended for primary care clinicians, family physicians, medical scholars, and other clinicians who treat and manage patients.

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Table of contents (12 chapters)

Front matter, bioprogressive paradigm in physiotherapeutic and antiaging strategies: a review.

  • Mieczyslaw Pokorski, Giovanni Barassi, Rosa G. Bellomo, Loris Prosperi, Matteo Crudeli, Raoul Saggini

Influence of Proprioceptive Neuromuscular Facilitation on Lung Function in Patients After Coronary Artery Bypass Graft Surgery

  • Małgorzata Bujar-Misztal, Andrzej Chciałowski

Remote Ischemic Preconditioning in Renal Protection During Elective Percutaneous Coronary Intervention

  • Małgorzata Wojciechowska, Maciej Zarębiński, Piotr Pawluczuk, Dagmara Gralak-Łachowska, Leszek Pawłowski, Wioletta Loska et al.

Prognostic Impact of Extracapsular Lymph Node Invasion on Survival in Non-small-Cell Lung Cancer: A Systematic Review and Meta-analysis

  • Seyed Vahid Tabatabaei, Christoph Nitche, Maximilian Michel, Kurt Rasche, Khosro Hekmat

Influence of Transurethral Resection of Bladder Cancer on Sexual Function, Anxiety, and Depression

  • Wojciech Krajewski, Urszula Halska, Sławomir Poletajew, Radosław Piszczek, Bartosz Bieżyński, Mateusz Matyjasek et al.

Cognitive Predictors of Cortical Thickness in Healthy Aging

  • Patrycja Naumczyk, Angelika K. Sawicka, Beata Brzeska, Agnieszka Sabisz, Krzysztof Jodzio, Marek Radkowski et al.

Osteoprotegerin, Receptor Activator of Nuclear Factor Kappa B Ligand, and Growth Hormone/Insulin-Like Growth Factor-1 Axis in Children with Growth Hormone Deficiency

  • Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Maria Sobol, Urszula Demkow, Beata Pyrżak

Inhibition of Cross-Reactive Carbohydrate Determinants in Allergy Diagnostics

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Effects of Glutathione on Hydrolytic Enzyme Activity in the Mouse Hepatocytes

  • Iwona Stanisławska, Bożena Witek, Marek Łyp, Danuta Rochon-Szmejchel, Adam Wróbel, Wojciech Fronczyk et al.

Adaptation to Occupational Exposure to Moderate Endotoxin Concentrations: A Study in Sewage Treatment Plants in Germany

  • M. A. Rieger, V. Liebers, M. Nübling, T. Brüning, B. Brendel, F. Hoffmeyer et al.

Effects of Low-Level Laser Therapy in Autism Spectrum Disorder

  • Gerry Leisman, Calixto Machado, Yanin Machado, Mauricio Chinchilla-Acosta

Epidemiology of Granulomatosis with Polyangiitis in Poland, 2011–2015

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Editors and Affiliations

Mieczyslaw Pokorski

About the editor

Bibliographic information.

Book Title : Clinical Medicine Research

Editors : Mieczyslaw Pokorski

Series Title : Advances in Experimental Medicine and Biology

DOI : https://doi.org/10.1007/978-3-030-04837-2

Publisher : Springer Cham

eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)

Copyright Information : The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2018

Hardcover ISBN : 978-3-030-04836-5 Published: 04 December 2018

eBook ISBN : 978-3-030-04837-2 Published: 23 November 2018

Series ISSN : 0065-2598

Series E-ISSN : 2214-8019

Edition Number : 1

Number of Pages : VI, 138

Number of Illustrations : 13 b/w illustrations, 6 illustrations in colour

Topics : Neurochemistry , Cancer Research , Physiotherapy , Cytokines and Growth Factors

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Clinical trials articles from across Nature Portfolio

A clinical trial involves the study of the safety, efficacy and/or dosage regimen of a therapeutic intervention (such as a drug) in humans selected according to predetermined criteria of eligibility (such as a defined severity of a specific disease), who are observed for predefined evidence of favourable and unfavourable effects.

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Integrating liver endpoints in clinical trials of cardiovascular and kidney disease

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In-Clinic and Natural Gait Observations master protocol (I-CAN-GO) to validate gait using a lumbar accelerometer

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Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

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Phase II trial of elotuzumab with pomalidomide and dexamethasone for daratumumab-refractory multiple myeloma

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Simplifying obstetric sonography with AI

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HIV prevention through PrEP in cisgender women

A large randomized controlled trial with cisgender women highlights the challenges of adherence to a daily oral preexposure prophylaxis regimen and demonstrates that twice-yearly injection of lenacapavir can maintain effective HIV prevention levels over 6 months.

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Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study

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clinical medicine research

Bile acid malabsorption (BAM) is characterized by chronic watery diarrhea resulting from excessive bile acids in the feces. BAM is often an overlooked cause of chronic diarrhea, with its prevalence not being sufficiently researched.

clinical medicine research

The field of kidney transplantation is being revolutionized by the integration of artificial intelligence (AI) and machine learning (ML) techniques. AI equips machines with human-like cognitive abilities, while ML enables computers to learn from data.

clinical medicine research

Acute kidney injury (AKI) affects increasing numbers of in-hospital patients in Central Europe and the USA, the prognosis remains poor. Although substantial progress has been achieved in the identification of molecular/cellular processes that induce and perpetuate AKI, more integrated pathophysiological perspectives are missing.

clinical medicine research

Subjects with mild cognitive impairment (MCI) can progress to dementia. Studies have shown that neuropsychological tests, biological or radiological markers individually or in combination have helped to determine the risk of conversion from MCI to dementia.

clinical medicine research

Atrial fibrillation (AF) is the most common arrhythmia with a growing prevalence worldwide, especially in the elderly population. Patients with AF are at higher risk of serious life-threatening events and complications that may lead to long-term sequelae and reduce quality of life.

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Acute kidney injury (AKI) affects up to 30% of all hospitalized patients in Central Europe and the USA. New biomarker molecules have been identified in recent years; most studies performed so far however aimed to identify markers for diagnostic purposes.


Pancreatic cancer is gastrointestinal cancer with a poor prognosis. Although surgical techniques and chemotherapy have improved treatment outcomes, the 5-year survival rate for pancreatic cancer is less than 10%.

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We present a case of a 40-year-old Caucasian male with past medical history of polysubstance abuse (cocaine and methamphetamine), who presented to the emergency department (ED) complaining of intermittent cough with associated chest discomfort and shortness of breath for 2 weeks.

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Marta Maci , Carlotta Fanelli, Mauro Lorusso, Donatella Ferrara, Marino Caroprese, Michele Laurenziello, Michele Tepedino, Domenico Ciavarella 273-283
doi: https://doi.org/10.14740/jocmr5202

Original Article

Sengottaian Sivakumar, Roni Mendonca, Michael Girshin 284-292
doi: https://doi.org/10.14740/jocmr5159
Chiara Rosato, Marilena Greco, Giovanni Marciante, Roberta Assunta Lazzari, Floriano Indino, Giambattista Lobreglio 293-301
doi: https://doi.org/10.14740/jocmr5070
Charlotte Mund, Katharina Asmus, Wajima Safi, Oliver Ritter, Dominique Petrus, Susann Patschan, Daniel Patschan 302-309
doi: https://doi.org/10.14740/jocmr5190
Anas Elgenidy, Mohammed Al-Mahdi Al-Kurdi, Hoda Atef Abdelsattar Ibrahim , Eman F. Gad, Ahmed K. Awad, Rebecca Caruana, Sheriseane Diacono, Aya Sherif, Tasneem Elattar, Islam E. Al-Ghanam, Asmaa M. Eldmaty, Tareq M. Abubasheer, Ahmed M. Afifi, Amira Elhoufey, Hamad Ghaleb Dailah, Amira M. Osman, Mohamed Ezzat, Doaa Ali Gamal, Rady Elmonier, Ahmed El-Sayed Hammour, Maged T. Abougabal, Khaled Saad 310-318
doi: https://doi.org/10.14740/jocmr5205

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Ashley Smith, Sidhant Kalsotra, Joseph D. Tobias 319-323
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Nih clinical research trials and you.

The NIH Clinical Trials and You website is a resource for people who want to learn more about clinical trials. By expanding the below questions, you can read answers to common questions about taking part in a clinical trial. 

What are clinical trials and why do people participate?

Clinical research is medical research that involves people like you. When you volunteer to take part in clinical research, you help doctors and researchers learn more about disease and improve health care for people in the future. Clinical research includes all research that involves people.  Types of clinical research include:

A potential volunteer talks with her doctor about participating in a clinical trial.

  • Epidemiology, which improves the understanding of a disease by studying patterns, causes, and effects of health and disease in specific groups.
  • Behavioral, which improves the understanding of human behavior and how it relates to health and disease.
  • Health services, which looks at how people access health care providers and health care services, how much care costs, and what happens to patients as a result of this care.
  • Clinical trials, which evaluate the effects of an intervention on health outcomes.

What are clinical trials and why would I want to take part?

Clinical trials are part of clinical research and at the heart of all medical advances. Clinical trials look at new ways to prevent, detect, or treat disease. Clinical trials can study:

  • New drugs or new combinations of drugs
  • New ways of doing surgery
  • New medical devices
  • New ways to use existing treatments
  • New ways to change behaviors to improve health
  • New ways to improve the quality of life for people with acute or chronic illnesses.

The goal of clinical trials is to determine if these treatment, prevention, and behavior approaches are safe and effective. People take part in clinical trials for many reasons. Healthy volunteers say they take part to help others and to contribute to moving science forward. People with an illness or disease also take part to help others, but also to possibly receive the newest treatment and to have added (or extra) care and attention from the clinical trial staff. Clinical trials offer hope for many people and a chance to help researchers find better treatments for others in the future

Why is diversity and inclusion important in clinical trials?

People may experience the same disease differently. It’s essential that clinical trials include people with a variety of lived experiences and living conditions, as well as characteristics like race and ethnicity, age, sex, and sexual orientation, so that all communities benefit from scientific advances.

See Diversity & Inclusion in Clinical Trials for more information.

How does the research process work?

The idea for a clinical trial often starts in the lab. After researchers test new treatments or procedures in the lab and in animals, the most promising treatments are moved into clinical trials. As new treatments move through a series of steps called phases, more information is gained about the treatment, its risks, and its effectiveness.

What are clinical trial protocols?

Clinical trials follow a plan known as a protocol. The protocol is carefully designed to balance the potential benefits and risks to participants, and answer specific research questions. A protocol describes the following:

  • The goal of the study
  • Who is eligible to take part in the trial
  • Protections against risks to participants
  • Details about tests, procedures, and treatments
  • How long the trial is expected to last
  • What information will be gathered

A clinical trial is led by a principal investigator (PI). Members of the research team regularly monitor the participants’ health to determine the study’s safety and effectiveness.

What is an Institutional Review Board?

Most, but not all, clinical trials in the United States are approved and monitored by an Institutional Review Board (IRB) to ensure that the risks are reduced and are outweighed by potential benefits. IRBs are committees that are responsible for reviewing research in order to protect the rights and safety of people who take part in research, both before the research starts and as it proceeds. You should ask the sponsor or research coordinator whether the research you are thinking about joining was reviewed by an IRB.

What is a clinical trial sponsor?

Clinical trial sponsors may be people, institutions, companies, government agencies, or other organizations that are responsible for initiating, managing or financing the clinical trial, but do not conduct the research.

What is informed consent?

Informed consent is the process of providing you with key information about a research study before you decide whether to accept the offer to take part. The process of informed consent continues throughout the study. To help you decide whether to take part, members of the research team explain the details of the study. If you do not understand English, a translator or interpreter may be provided. The research team provides an informed consent document that includes details about the study, such as its purpose, how long it’s expected to last, tests or procedures that will be done as part of the research, and who to contact for further information. The informed consent document also explains risks and potential benefits. You can then decide whether to sign the document. Taking part in a clinical trial is voluntary and you can leave the study at any time.

What are the types of clinical trials?

There are different types of clinical trials.

Why do researchers do different kinds of clinical studies?

  • Prevention trials look for better ways to prevent a disease in people who have never had the disease or to prevent the disease from returning. Approaches may include medicines, vaccines, or lifestyle changes.
  • Screening trials test new ways for detecting diseases or health conditions.
  • Diagnostic trials study or compare tests or procedures for diagnosing a particular disease or condition.
  • Treatment trials test new treatments, new combinations of drugs, or new approaches to surgery or radiation therapy.
  • Behavioral trials evaluate or compare ways to promote behavioral changes designed to improve health.
  • Quality of life trials (or supportive care trials) explore and measure ways to improve the comfort and quality of life of people with conditions or illnesses.

What are the phases of clinical trials?

Clinical trials are conducted in a series of steps called “phases.” Each phase has a different purpose and helps researchers answer different questions.

  • Phase I trials : Researchers test a drug or treatment in a small group of people (20–80) for the first time. The purpose is to study the drug or treatment to learn about safety and identify side effects.
  • Phase II trials : The new drug or treatment is given to a larger group of people (100–300) to determine its effectiveness and to further study its safety.
  • Phase III trials : The new drug or treatment is given to large groups of people (1,000–3,000) to confirm its effectiveness, monitor side effects, compare it with standard or similar treatments, and collect information that will allow the new drug or treatment to be used safely.
  • Phase IV trials : After a drug is approved by the FDA and made available to the public, researchers track its safety in the general population, seeking more information about a drug or treatment’s benefits, and optimal use.

What do the terms placebo, randomization, and blinded mean in clinical trials?

In clinical trials that compare a new product or therapy with another that already exists, researchers try to determine if the new one is as good, or better than, the existing one. In some studies, you may be assigned to receive a placebo (an inactive product that resembles the test product, but without its treatment value).

Comparing a new product with a placebo can be the fastest and most reliable way to show the new product’s effectiveness. However, placebos are not used if you would be put at risk — particularly in the study of treatments for serious illnesses — by not having effective therapy. You will be told if placebos are used in the study before entering a trial.

Randomization is the process by which treatments are assigned to participants by chance rather than by choice. This is done to avoid any bias in assigning volunteers to get one treatment or another. The effects of each treatment are compared at specific points during a trial. If one treatment is found superior, the trial is stopped so that the most volunteers receive the more beneficial treatment.  This video helps explain randomization for all clinical trials .

" Blinded " (or " masked ") studies are designed to prevent members of the research team and study participants from influencing the results. Blinding allows the collection of scientifically accurate data. In single-blind (" single-masked ") studies, you are not told what is being given, but the research team knows. In a double-blind study, neither you nor the research team are told what you are given; only the pharmacist knows. Members of the research team are not told which participants are receiving which treatment, in order to reduce bias. If medically necessary, however, it is always possible to find out which treatment you are receiving.

Who takes part in clinical trials?

Many different types of people take part in clinical trials. Some are healthy, while others may have illnesses. Research procedures with healthy volunteers are designed to develop new knowledge, not to provide direct benefit to those taking part. Healthy volunteers have always played an important role in research.

Healthy volunteers are needed for several reasons. When developing a new technique, such as a blood test or imaging device, healthy volunteers help define the limits of "normal." These volunteers are the baseline against which patient groups are compared and are often matched to patients on factors such as age, gender, or family relationship. They receive the same tests, procedures, or drugs the patient group receives. Researchers learn about the disease process by comparing the patient group to the healthy volunteers.

Factors like how much of your time is needed, discomfort you may feel, or risk involved depends on the trial. While some require minimal amounts of time and effort, other studies may require a major commitment of your time and effort, and may involve some discomfort. The research procedure(s) may also carry some risk. The informed consent process for healthy volunteers includes a detailed discussion of the study's procedures and tests and their risks.

A patient volunteer has a known health problem and takes part in research to better understand, diagnose, or treat that disease or condition. Research with a patient volunteer helps develop new knowledge. Depending on the stage of knowledge about the disease or condition, these procedures may or may not benefit the study participants.

Patients may volunteer for studies similar to those in which healthy volunteers take part. These studies involve drugs, devices, or treatments designed to prevent,or treat disease. Although these studies may provide direct benefit to patient volunteers, the main aim is to prove, by scientific means, the effects and limitations of the experimental treatment. Therefore, some patient groups may serve as a baseline for comparison by not taking the test drug, or by receiving test doses of the drug large enough only to show that it is present, but not at a level that can treat the condition.

Researchers follow clinical trials guidelines when deciding who can participate, in a study. These guidelines are called Inclusion/Exclusion Criteria . Factors that allow you to take part in a clinical trial are called "inclusion criteria." Those that exclude or prevent participation are "exclusion criteria." These criteria are based on factors such as age, gender, the type and stage of a disease, treatment history, and other medical conditions. Before joining a clinical trial, you must provide information that allows the research team to determine whether or not you can take part in the study safely. Some research studies seek participants with illnesses or conditions to be studied in the clinical trial, while others need healthy volunteers. Inclusion and exclusion criteria are not used to reject people personally. Instead, the criteria are used to identify appropriate participants and keep them safe, and to help ensure that researchers can find new information they need.

What do I need to know if I am thinking about taking part in a clinical trial?

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Risks and potential benefits

Clinical trials may involve risk, as can routine medical care and the activities of daily living. When weighing the risks of research, you can think about these important factors:

  • The possible harms that could result from taking part in the study
  • The level of harm
  • The chance of any harm occurring

Most clinical trials pose the risk of minor discomfort, which lasts only a short time. However, some study participants experience complications that require medical attention. In rare cases, participants have been seriously injured or have died of complications resulting from their participation in trials of experimental treatments. The specific risks associated with a research protocol are described in detail in the informed consent document, which participants are asked to consider and sign before participating in research. Also, a member of the research team will explain the study and answer any questions about the study. Before deciding to participate, carefully consider risks and possible benefits.

Potential benefits

Well-designed and well-executed clinical trials provide the best approach for you to:

  • Help others by contributing to knowledge about new treatments or procedures.
  • Gain access to new research treatments before they are widely available.
  • Receive regular and careful medical attention from a research team that includes doctors and other health professionals.

Risks to taking part in clinical trials include the following:

  • There may be unpleasant, serious, or even life-threatening effects of experimental treatment.
  • The study may require more time and attention than standard treatment would, including visits to the study site, more blood tests, more procedures, hospital stays, or complex dosage schedules.

What questions should I ask if offered a clinical trial?

If you are thinking about taking part in a clinical trial, you should feel free to ask any questions or bring up any issues concerning the trial at any time. The following suggestions may give you some ideas as you think about your own questions.

  • What is the purpose of the study?
  • Why do researchers think the approach may be effective?
  • Who will fund the study?
  • Who has reviewed and approved the study?
  • How are study results and safety of participants being monitored?
  • How long will the study last?
  • What will my responsibilities be if I take part?
  • Who will tell me about the results of the study and how will I be informed?

Risks and possible benefits

  • What are my possible short-term benefits?
  • What are my possible long-term benefits?
  • What are my short-term risks, and side effects?
  • What are my long-term risks?
  • What other options are available?
  • How do the risks and possible benefits of this trial compare with those options?

Participation and care

  • What kinds of therapies, procedures and/or tests will I have during the trial?
  • Will they hurt, and if so, for how long?
  • How do the tests in the study compare with those I would have outside of the trial?
  • Will I be able to take my regular medications while taking part in the clinical trial?
  • Where will I have my medical care?
  • Who will be in charge of my care?

Personal issues

  • How could being in this study affect my daily life?
  • Can I talk to other people in the study?

Cost issues

  • Will I have to pay for any part of the trial such as tests or the study drug?
  • If so, what will the charges likely be?
  • What is my health insurance likely to cover?
  • Who can help answer any questions from my insurance company or health plan?
  • Will there be any travel or child care costs that I need to consider while I am in the trial?

Tips for asking your doctor about trials

  • Consider taking a family member or friend along for support and for help in asking questions or recording answers.
  • Plan what to ask — but don't hesitate to ask any new questions.
  • Write down questions in advance to remember them all.
  • Write down the answers so that they’re available when needed.
  • Ask about bringing a tape recorder to make a taped record of what's said (even if you write down answers).

This information courtesy of Cancer.gov.

How is my safety protected?

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Ethical guidelines

The goal of clinical research is to develop knowledge that improves human health or increases understanding of human biology. People who take part in clinical research make it possible for this to occur. The path to finding out if a new drug is safe or effective is to test it on patients in clinical trials. The purpose of ethical guidelines is both to protect patients and healthy volunteers, and to preserve the integrity of the science.

Informed consent

Informed consent is the process of learning the key facts about a clinical trial before deciding whether to participate. The process of providing information to participants continues throughout the study. To help you decide whether to take part, members of the research team explain the study. The research team provides an informed consent document, which includes such details about the study as its purpose, duration, required procedures, and who to contact for various purposes. The informed consent document also explains risks and potential benefits.

If you decide to enroll in the trial, you will need to sign the informed consent document. You are free to withdraw from the study at any time.

Most, but not all, clinical trials in the United States are approved and monitored by an Institutional Review Board (IRB) to ensure that the risks are minimal when compared with potential benefits. An IRB is an independent committee that consists of physicians, statisticians, and members of the community who ensure that clinical trials are ethical and that the rights of participants are protected. You should ask the sponsor or research coordinator whether the research you are considering participating in was reviewed by an IRB.

Further reading

For more information about research protections, see:

  • Office of Human Research Protection
  • Children's Assent to Clinical Trial Participation

For more information on participants’ privacy and confidentiality, see:

  • HIPAA Privacy Rule
  • The Food and Drug Administration, FDA’s Drug Review Process: Ensuring Drugs Are Safe and Effective

For more information about research protections, see: About Research Participation

What happens after a clinical trial is completed?

After a clinical trial is completed, the researchers carefully examine information collected during the study before making decisions about the meaning of the findings and about the need for further testing. After a phase I or II trial, the researchers decide whether to move on to the next phase or to stop testing the treatment or procedure because it was unsafe or not effective. When a phase III trial is completed, the researchers examine the information and decide whether the results have medical importance.

Results from clinical trials are often published in peer-reviewed scientific journals. Peer review is a process by which experts review the report before it is published to ensure that the analysis and conclusions are sound. If the results are particularly important, they may be featured in the news, and discussed at scientific meetings and by patient advocacy groups before or after they are published in a scientific journal. Once a new approach has been proven safe and effective in a clinical trial, it may become a new standard of medical practice.

Ask the research team members if the study results have been or will be published. Published study results are also available by searching for the study's official name or Protocol ID number in the National Library of Medicine's PubMed® database .

How does clinical research make a difference to me and my family?

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Only through clinical research can we gain insights and answers about the safety and effectiveness of treatments and procedures. Groundbreaking scientific advances in the present and the past were possible only because of participation of volunteers, both healthy and those with an illness, in clinical research. Clinical research requires complex and rigorous testing in collaboration with communities that are affected by the disease. As research opens new doors to finding ways to diagnose, prevent, treat, or cure disease and disability, clinical trial participation is essential to help us find the answers.

This page last reviewed on October 3, 2022

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Physician Residency

  • Research: Clinical Departments
  • Radiation Oncology: Home
  • Radiation Oncology: Education > Physician Residency

Thank you for your interest in our Physician Residency training program. It is an exciting time in radiation oncology with technological advances and molecular breakthroughs improving our understanding of cancer. UCI is at the forefront of academic medicine, ushering innovative ideas from the laboratory to the bedside. The Department of Radiation Oncology at UCI continues to grow at an unprecedented pace.

Our talented and renowned faculty are recognized as patient advocates, pioneers in research and leaders in academic radiation oncology. They are dedicated educators who are also approachable and down-to-earth. We believe it is the faculty, coupled with our unwavering commitment to cutting-edge technology, basic and translational research, clinical trials and multidisciplinary patient-centered cancer care, that create a dynamic training environment.

Get to Know Our Program

The Department of Radiation Oncology at UCI offers an exceptional residency training program, providing a dynamic environment with renowned faculty, innovative research, advanced technology and patient-centered cancer care.

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The Department expects residents to participate in hypothesis-driven, thematic-based research during training, and all residents are guaranteed six to 12 months of research time during the PGY-4 year. The specific length of research time afforded each resident will be based on the nature and quality of the proposed research as determined in advance by their research mentor(s), the residency program director and the department chair.

Residents have the discretion of tailoring their research in the form of biological laboratory research, clinical research or medical physics research under the supervision of a designated mentor. Basic research opportunities will not be limited to radiation research, but will be open to any cancer-related laboratory programs associated within the UCI School of Medicine and Comprehensive Cancer Center. The American Board of Radiology (ABR) Holman Pathway will be considered for exceptional candidates with a strong background in research. During the allocated research time, residents will be free of all clinical responsibilities and will not be expected to take call.

UCI is recognized as a leader in the burgeoning field of health services research. Opportunities exist for trainees to work with faculty in the Health Policy Research Institute (HPRI) through the Masters of Science in Biomedical and Translational Science (MS-BATS) and the Certificate Program in Clinical Research, which aims to produce leaders and agents for change in diverse settings such as the community, federal and state governments, health care organizations and academic departments. Residents with an interest in health services research are encouraged to pursue careers that play an active role in shaping and evaluating policies and programs to improve systems, with particular focus on care for those outside of society's mainstream.

The UCI Radiation Oncology Department believes that the foundation for achieving our goals is to embrace the quality imperative in everything we do. This includes safety and quality in our clinical care and research activities, as well as excellence in our educational endeavors and value in our community outreach initiatives. Residents are expected to participate in quality improvement and safety activities throughout training and are an integral part of the department’s commitment to quality assurance and patient safety.

In addition to weekly peer-review conferences, a monthly quality improvement meeting attended by representatives of all divisions of the department, including nursing, therapy and dosimetry, occurs on an ongoing basis for purposes of self-evaluation. As mandated by the University of California, residents are required to work with faculty mentors to develop initiatives to promote safety in the workplace through designated radiation oncology clinical quality initiative (CQI) projects, formulated in accordance with the program director and the Graduate Medical Education (GME) staff.

Project Manager: Clinical Practice & Research Partnerships

Job summary.

The Michigan Medicine Quality Department is seeking a skilled individual to provide support for the Michigan Program on Value Enhancement (MPrOVE). The Michigan Program on Value Enhancement (MPrOVE) is a multi-faceted strategic initiative designed to implement and evaluate innovative projects that improve the value of care at Michigan Medicine (MM) and research the implementation of novel ideas around value and right-sizing care. MPrOVE is jointly supported by the MM Quality Department and the Institute for Healthcare Policy & Innovation (IHPI).

This Project Manager will directly lead multiple MPrOVE projects that build research practice partnerships to improve patient care. These will include collaborative quality improvement and research projects aimed to reduce low-value care and bridge the gap between health services research and clinical operations at Michigan Medicine. This role will coordinate a team of physician researchers, clinicians, statisticians, analysts, and other stakeholders to coordinate the implementation and evaluation of impactful projects across the health system. This work is designed to accelerate the application of innovative research methods to facilitate the identification, assessment, and de-implementation of low-value services at MM and beyond. 

Depending on the skills and interests of the individual who takes this position, there will be flexibility regarding additional opportunities to support value-based project and research activities.

This is a full-time position working approximately 8:30am-5:00pm, Monday through Friday. 

This position will be eligible for a remote first approach to work location, however, there are some required in-person meetings which occur approximately once per week (4 times per month). Flexible work opportunities are determined at the discretion of the hiring department. Flexible work agreements are reviewed annually and are subject to change dependent on the business needs of the team throughout the course of employment.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world’s most distinguished academic health systems.  In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

  • Excellent medical, dental and vision coverage effective on your very first day
  • 2:1 Match on retirement savings

Responsibilities*

Project Management (60%)

  • Translate leadership priorities and goals into actionable project deliverables for specific MPrOVE projects. This includes tying MPrOVE projects to the health system priorities framework.
  • Independently lead projects that connect health system leaders with researchers to achieve impact. This will include conducting technical project work (such as project planning, intervention design, and quality improvement efforts), leading stakeholder coordination (facilitating meetings as well as collaborative decision-making), and developing research dissemination content in partnership with faculty (such as abstracts, presentations, and manuscripts). 
  • Independently produce detailed timelines and resource plans, define requirements, create project documentation, report status to team and stakeholders through project summaries and progress tracking, track and solve issues with team members and work with faculty to complete necessary activities that drive progress.
  • Draft, edit, and format communications, documents, and reports using Word, Excel and PowerPoint for use in a variety of venues with diverse audiences including senior leaders and external stakeholders.  
  • Manage project resources, including budgets, staff time, faculty time, and stakeholder capital, to design, implement, and evaluate impactful value-based quality improvement projects.
  • Build and sustain working relationships across different levels of the organization, including connections throughout all levels of the Quality Department, MM, and IHPI, as well as establishing connections within key clinical divisions involved in specific projects. 
  • Devise innovative solutions to any problems that may arise during the course of the project, and take appropriate actions to resolve without waiting for direction.

Research Responsibilities (25%)

  • Work collaboratively with faculty members, analysts, and data teams to develop evaluation and  research approaches. 
  • Cooperate with physician faculty, PhD researchers, analysts, and other partners to plan and execute surveys, qualitative interviews, mixed-methods projects, and/or research projects on value of care at MM.
  • Collect or direct other team members to organize and analyze medical chart data (the electronic health record; EPIC/MiChart).. 
  • Assist with IRB requirements. 
  • Coordinate the development of collaborative academic products and research presentations.  

Coordinate MPrOVE Learner Program (10%)

  • In coordination with other MPrOVE staff and leaders, work to develop and coordinate the MPrOVE Learner Program, which will actively engage students and learners from multiple disciplines, particularly those interested in value, de-implementation, and research. 
  • Tasks will include coordination of learning/training sessions, actively engaging with students, and at times facilitating open dialogue among learners about projects, emerging research, and additional topics related to value and research.

Additional Activities and Tasks as Needed (5%)

  • As needed, provide high-level project management expertise leading to the advancement of the MPrOVE Program.
  • Other duties as assigned.

Required Qualifications*

  • Bachelor's degree.
  • 5+ years of relevant experience such as quality improvement, projects related to health services data/research, or quality of care in adult or pediatric populations. 
  • 3+ years of experience working directly with clinical operations team leaders and physician faculty.
  • Ability to consistently meet deadlines for multiple projects and stakeholders in a fast-paced environment with competing tasks and priorities.
  • Strong skills related to collaboration, active listening, interpersonal communication, meeting facilitation.
  • Detail oriented with strong organizational, communication, and advanced problem-solving skills. 
  • Experience with research methods such as surveys, qualitative interviews, or analytic approaches.
  • Experience with quality improvement, implementation science, healthcare evaluation and health services research.
  • Experience with the academic research process including protocol development, data collection and management, and dissemination of academic products.

Desired Qualifications*

  • Advanced technical skills and expertise related to quality improvement, implementation science, or health services research.
  • Familiarity with value-based care, research practice partnerships, or translational research . 

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes .

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

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The University of Michigan is an equal opportunity/affirmative action employer.

COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

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Clinical Research Coordinator - Rheumatology

  • Columbia University Medical Center
  • Opening on: Sep 5 2024
  • Job Type: Officer of Administration
  • Regular/Temporary: Regular
  • Hours Per Week: 35
  • Salary Range: $62,400 - $65,000

Position Summary

The Clinical Research Coordinator will support multiple research studies (government, private and pharmaceutical) through the coordination and implementation of clinical trials and protocols involving human subjects

Responsibilities

  • Facilitate screening, enrollment and treatment of research subjects in compliance with established regulations, guidelines and internal standard operating procedures.
  • Assist with eligibility assessment and obtaining written informed consent as appropriate.
  • Function as a liaison with sponsoring agencies and external sites.
  • Responsible for sample collection, processing and storage activities.
  • Assist with regulatory submissions including protocol review and monitoring.
  • Ensure regulatory documents and administrative files for each protocol are up-to-date and adhere to sponsor requirements.
  • Maintain Study Manager data entry for all assigned studies.
  • Assist with short-term projects and provide cross coverage to various research team members as needed.
  • Perform other duties and responsibilities as needed.

Minimum Qualifications

  • Bachelor's degree or equivalent in education, training and experience, plus two years of related experience
  • Excellent organizational, writing and verbal communications skills

Other Requirements

  • Contact with patients and/or human research subjects
  • Potential bloodborne pathogen exposure
  • Successful completion of applicable compliance and systems training requirements

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Columbia University is committed to the hiring of qualified local residents.

Commitment to Diversity 

Columbia university is dedicated to increasing diversity in its workforce, its student body, and its educational programs. achieving continued academic excellence and creating a vibrant university community require nothing less. in fulfilling its mission to advance diversity at the university, columbia seeks to hire, retain, and promote exceptionally talented individuals from diverse backgrounds.  , share this job.

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Clinical Research Coordinator

  • Madison, Wisconsin
  • SCHOOL OF MEDICINE AND PUBLIC HEALTH/RADIOLOGY-GEN
  • Partially Remote
  • Staff-Full Time
  • Staff-Part Time
  • Opening at: May 31 2024 at 09:55 CDT
  • Closing at: Sep 17 2024 at 23:55 CDT

Job Summary:

The Department of Radiology, University of Wisconsin - Madison, School of Medicine & Public Health is seeking a Clinical Research Coordinator (CRC) to help advance exciting medical imaging and disease-focused projects! The CRC works as part of a team, which includes physicians, PhD researchers, imaging staff, and other research support staff, to support and advance a portfolio of interesting research projects. Radiology projects focus on anything from the development of novel imaging techniques, to work towards understanding and curing disease. The role of a CRC is quite varied - an average day could include responsibilities ranging from recruiting and enrolling subjects into a study, to coordinating and conducting actual subject visits, to collaborations with the study team on a wide variety of topics.

Responsibilities:

Institutional statement on diversity:.

Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals. The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world. For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion

Preferred Bachelor's Degree

Qualifications:

Required - Research experience. Preferred - At least one year experience with clinical research studies. - Experience working within a higher education setting. - Prior experience working within a healthcare setting. The ideal candidate will have strong attention to detail and ability to think critically and/or strategically to solve problems.

Full or Part Time: 80% - 100% This position may require some work to be performed in-person, onsite, at a designated campus work location. Some work may be performed remotely, at an offsite, non-campus work location. The incumbent must have schedule flexibility to occasionally work outside of standard 8:00AM- 5:00PM weekday hours. The position occasionally requires travel to other, local UW locations.

Appointment Type, Duration:

Ongoing/Renewable

Minimum $48,000 ANNUAL (12 months) Depending on Qualifications The starting full time salary for the position is $48,000 but commensurate with experience and qualifications. Actual pay is determined at hire and is based on experience and qualifications. Employees in this position can expect to receive benefits such as generous vacation, holidays, and sick leave; competitive insurances and savings accounts; retirement benefits. Benefits information can be found at ( https://hr.wisc.edu/benefits/ ).

Additional Information:

Applicants for this position will be considered for the titles listed in this posting. The title is determined by the experience and qualifications of the finalist. This position has been identified as a position of trust with access to vulnerable populations. The selected candidate will be required to pass an initial caregiver check to be eligible for employment under the Wisconsin Caregiver Law and every four years. University sponsorship is not available for this position, including transfers of sponsorship. The selected applicant will be responsible for ensuring their continuous eligibility to work in the United States (i.e. a citizen or national of the United States, a lawful permanent resident, a foreign national authorized to work in the United States without the need of an employer sponsorship) on or before the effective date of appointment. This position is an ongoing position that will require continuous work eligibility. UW-Madison is not an E-Verify employer, and therefore, is not eligible to employ F1-OPT STEM Extension participants. If you are selected for this position you must provide proof of work authorization and eligibility to work.

How to Apply:

To apply for this position, please click on the "Apply Now" button. You will be asked to upload a current resume/CV and a cover letter briefly describing your qualifications and experience.

Amanda Joncas [email protected] 608-262-2716 Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information.

Official Title:

Clin Res Coord I(RE015) or Clin Res Coord II(RE016)

Department(s):

A53-MEDICAL SCHOOL/RADIOLOGY/RADIOLOGY

Employment Class:

Academic Staff-Renewable

Job Number:

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  1. Clinical Medicine & Research

    Current Issue Highlights: Cardiovascular Death and Liver Disease: Mortality Trends and Disparities. COVID-19-Related Treatment Cancellations and Oncology Patients' Psychological Health in Nigeria. Assessment of the Prophylactic Effects of Probiotics, Prebiotics, and Synbiotics Against COVID-19: A Systematic Review of Randomized Controlled Trials.

  2. Clinical Medicine

    Clinical Medicine is a peer-reviewed journal of the Royal College of Physicians that publishes advances and reviews in medicine. It offers open access articles on various topics, special issues, and a discounted article publishing charge until 31 December 2024.

  3. Clinical Trials and Clinical Research: A Comprehensive Review

    Clinical research is an alternative terminology used to describe medical research. Clinical research involves people, and it is generally carried out to evaluate the efficacy of a therapeutic drug, a medical/surgical procedure, or a device as a part of treatment and patient management. Moreover, any research that evaluates the aspects of a ...

  4. Clinical Research What is It

    What is clinical research, and is it right for you? Clinical research is the comprehensive study of the safety and effectiveness of the most promising advances in patient care. Clinical research is different than laboratory research. It involves people who volunteer to help us better understand medicine and health.

  5. CM&R About Clinical Medicine & Research

    Clinical Medicine & Research is a peer reviewed publication of original scientific medical research that is relevant to a broad audience of medical researchers and healthcare professionals.Clinical Medicine & Research publishes collections of articles in quarterly issues of the journal and, upon acceptance, author manuscripts are published electronically in the RAPID RELEASE section of this ...

  6. The New England Journal of Medicine

    E.D. Gaier and Others. Images in Clinical Medicine. Aug 17, 2024. J.M. Hernández Pérez. The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical ...

  7. The next generation of evidence-based medicine

    The concept of medical analog patient-specific 'digital twins' is an emerging area of research that has the potential to combine polynomial data (mechanistic data, medical history, with the ...

  8. Clinical Medicine

    R.P. Walensky and OthersN Engl J Med 2024;391:845-852. One hundred years ago, a 24-year-old man was admitted to the hospital because of fever, cough, and shortness of breath. The patient died on ...

  9. Clinical Medicine Research

    This book covers various topics in medical disciplines, such as physiotherapy, coronary disease, cancer, and autism. It aims to provide new insights and perspectives on clinical research and practice for clinicians and scholars.

  10. Clinical Practice Topics

    Case Studies in Social Medicine; Childhood Cancer; Childhood Diseases; Chronic Kidney Disease; Climate Change General; Climate Crisis and Health; Clinical Medicine General; Clinical Trials Series ...

  11. What is Clinical Research?

    Office of Inspector General. USA.gov. NIH…Turning Discovery Into Health ®. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892. U.S. Department of Health and Human Services. Clinical research occurs in many formats and can involve anyone. Learn how you can participate and contribute to medical advances.

  12. Clinical trials

    Clinical trials articles from across Nature Portfolio. ... Research Highlights 29 Aug 2024 Nature Medicine. ... Research Highlights 05 Aug 2024 Nature Reviews Gastroenterology & Hepatology.

  13. Clinical Research Resources

    The JH-OCT brings together three groups in the school of medicine Office of Research Administration that provide essential services to efficiently move clinical trials contracts and budgets forward: clinical research contracting, clinical research support services and clinical research billing compliance. JH-OCT is the gateway for clinical ...

  14. Journal of Clinical Medicine Research

    A peer-reviewed journal that publishes original research and reviews on various topics in clinical medicine. Find articles on bile acid malabsorption, kidney transplantation, acute kidney injury, dementia, atrial fibrillation, and more.

  15. Journal of Clinical Medicine

    Journal of Clinical Medicine is an international, peer-reviewed, open access journal of clinical medicine, published semimonthly online by MDPI.The International Bone Research Association (IBRA), Italian Resuscitation Council (IRC), Spanish Society of Hematology and Hemotherapy (SEHH), Japan Association for Clinical Engineers (JACE), European Independent Foundation in Angiology/ Vascular ...

  16. Marshfield Clinic Research Institute

    Clinical Medicine & Research has an H index of 62 (2023), an SJR of 0.334 (2023) with a 2-year Cites per Doc of 1.017 (2023). Please visit Scimago's page for Clinical Medicine & Research to learn more about the definition of these journal measures of scientific influence.

  17. The Basics

    Clinical research includes all research that involves people. Types of clinical research include: Epidemiology, which improves the understanding of a disease by studying patterns, causes, and effects of health and disease in specific groups. Behavioral, which improves the understanding of human behavior and how it relates to health and disease.

  18. CM&R Clinical Medicine & Research Information for Authors

    Clinical Medicine & Research is a peer-reviewed medical research journal presenting relevant, credible information that addresses topics of interest to a multi-specialty audience in medicine, preventive medicine, translational medicine, epidemiology, research, and basic science. Clinical Medicine & Research will consider original manuscripts ...

  19. Research Information at Johns Hopkins Medicine

    At the foundation of Johns Hopkins Medicine is research — from basic research, where scientists study cells and mechanisms, to clinical research that builds on those findings using trials, to translational research that takes information learned from trials to the patient bedside. Browse Research Topics.

  20. Archive of "Clinical Medicine & Research".

    Articles from Clinical Medicine & Research are provided here courtesy of Marshfield Clinic. Follow NCBI. Connect with NLM. National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894. Web Policies FOIA HHS Vulnerability Disclosure. Help Accessibility Careers. NLM; NIH; HHS; USA.gov ...

  21. Clinical Medicine & Research

    Clinical Medicine & Research is an open-access, peer-reviewed, academic journal of clinical medicine published by the Marshfield Clinic Research Foundation. The journal is currently edited by Adedayo A. Onitilo (Marshfield Clinic). Abstracting and indexing. The journal is abstracted and indexed in the following bibliographic databases:

  22. Orthopedic Clinical Research

    The Blue Ridge Institute for Medical Research currently has the department ranked third in funding for orthopedic departments of public medical schools. ... Even the most impactful findings from clinical research studies can take years to make it into widespread clinical practice. Cutting that lag time and smoothing the path to uptake is the ...

  23. Radiation Oncology: Education > Physician Residency

    Residents have the discretion of tailoring their research in the form of biological laboratory research, clinical research or medical physics research under the supervision of a designated mentor. Basic research opportunities will not be limited to radiation research, but will be open to any cancer-related laboratory programs associated within ...

  24. Project Manager: Clinical Practice & Research Partnerships

    This Project Manager will directly lead multiple MPrOVE projects that build research practice partnerships to improve patient care. These will include collaborative quality improvement and research projects aimed to reduce low-value care and bridge the gap between health services research and clinical operations at Michigan Medicine.

  25. PDF Clinical Medicine & Research

    Clinical Medicine & Research is committed to providing its readership with relevant, rigorously peer reviewed, original scientific medical re-search that substantially improves human health and well-being. Clinical Medicine & Research is available in print and electronic formats. Full

  26. Clinical Research Coordinator

    Job Type: Officer of Administration Regular/Temporary: Regular Hours Per Week: 35 Salary Range: $62,400 - $65,000 The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith ...

  27. Clinical Research Coordinator

    Job Summary: The Department of Radiology, University of Wisconsin - Madison, School of Medicine & Public Health is seeking a Clinical Research Coordinator (CRC) to help advance exciting medical imaging and disease-focused projects! The CRC works as part of a team, which includes physicians, PhD researchers, imaging staff, and other research support staff, to support and advance a portfolio of ...

  28. Clinical Research Coordinator I, Radiation Oncology job at UT

    Directly interacts with clinical research participants, as required, for the research study. Interacts via telephone, telehealth or in-person. ... we're committed to providing rigorous scientific training in both basic and clinical research to scholars across the Medical Center and community. You can take advantage or help support a number of ...